ABSTRACT
No disponible
Subject(s)
Humans , Female , Middle Aged , Waldenstrom Macroglobulinemia/pathology , Waldenstrom Macroglobulinemia/complications , Skin Diseases/etiology , Skin Diseases/pathology , Neoplasm Invasiveness , Fatal OutcomeABSTRACT
Hailey-Hailey disease, or familial benign chronic pemphigus, is a rare relapsing-remitting autosomal-dominant epidermal blistering disease. It preferentially affects females and is characterized by recurrent vesicles and erosions in the intertriginous areas. There are several topical corticosteroid therapeutic options, which are often limited in their use by their secondary effects and localization of the lesions. We report a case of a 60-year-old woman with Hailey-Hailey disease involving axillary, groin, cervical, antecubital, inframammary and abdominal folds. She was treated with 0.1% tacrolimus ointment, applied twice daily, with clinical improvement in 2 weeks and total remission in 4 weeks. She remains asymptomatic after a 10-month follow-up period.
Subject(s)
Adjuvants, Immunologic/administration & dosage , Pemphigus, Benign Familial/drug therapy , Tacrolimus/administration & dosage , Adjuvants, Immunologic/therapeutic use , Administration, Topical , Anti-Bacterial Agents/pharmacology , Clarithromycin/pharmacology , Female , Humans , Middle Aged , Pemphigus, Benign Familial/physiopathology , Tacrolimus/therapeutic useABSTRACT
Psoriasis is a chronic inflammatory skin disorder. Recent advances in the understanding of its immunological basis have led to its redefinition as being T-cell mediated. New biological agents have been developed as effective selective target therapies and promise to be an alternative to conventional systemic medications. Etanercept is a recombinant human protein recently approved for psoriatic arthritis treatment that has activity against tumor necrosis factor-alpha (TNF-alpha). It is composed of the human TNF receptor linked to the Fc portion of human IgG1. TNF-alpha seems to play a key role in the pathogenesis of psoriasis and psoriatic arthritis. Therefore, etanercept TNF antagonism is an effective approach for severe psoriasis. We describe two case reports of severe recalcitrant psoriasis, also with arthritis, that showed a remarkable improvement with etanercept, with no adverse events.
